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KMID : 0616120180490040305
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Korean Journal of Pharmacognosy
2018 Volume.49 No. 4 p.305 ~ p.311
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Sparassis crispa (Wulf.) Extract Inhibits IL-1b Stimulated Inflammatory Mediators Production on SW1353 Human Chondrocytes
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Kim Eun-Nam
Jeong Gil-Saeng
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Abstract
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Osteoarthritis (OA) is the most common form of joint disease, characterized by articular cartilage, osteonecrosis, and osteochondral bone erosion. It is an early, progressive disease that combines joint stiffness and joint pain and reduces cartilage function and condition. Interleukin-1 beta (IL-1b) is thought to be important to the pathogenesis of OA and significantly increases the expression of matrix metalloproteinases (MMPs), which play an important role in cartilage degradation in OA. Sparassis crispa (Wulf.) is an edible / medicinal mushroom that has been reported to variety of biological activities. In this study, investigated the Anti-inflammatory effect of Sparassis crispa (Wulf.) ethanol extract (SCE) on IL-1b stimulated SW1353 chondrocytes. SCE decreased the expression and activity of MMPs by IL-1b and decreased the levels of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) associated with the inhibition of prostaglandin E2(PGE2) in IL-1b stimulated SW-1353 chondrocytes. In addition, SCE inhibits the expression of MAPK (mitogen-activated protein kinase) and NF-kB (nuclear factor-kappa B) signaling in IL-1b stimulated SW-1353 cells, and SCE inhibits the production of reactive oxygen species (ROS) through heme oxygenase-1 (HO-1) expression. Thus, it is suggested that SCE has a potential as an anti-inflammatory agent in osteoarthritis treatments.
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KEYWORD
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Sparassis crispa (Wulf.) , Interleukin-1 beta (IL-1b) , Mitogen-activated protein kinase(MAPK) , NF-kB (nuclear factor-kappa B) , Heme oxygenase-1 (HO-1) , Reactive oxygen species (ROS)
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